• Source: Ahna Skop

Ahna Renee Skop is an American geneticist, artist, and a professor at the University of Wisconsin–Madison. She is known for her research on the mechanisms underlying asymmetric cell division, particularly the importance of the midbody in this process.




Education


Skop grew up in New Haven, Connecticut and Fort Thomas, Kentucky. She earned a Bachelor of Science in biology and a minor in Ceramics from Syracuse University and before completing her Ph.D. in cellular and molecular biology at the University of Wisconsin-Madison. She did postdoctoral work at the University of California, Berkeley in the laboratories of Rebecca Heald, Barbara Meyer and John Yates (Scripps), after which she returned to the University of Wisconsin–Madison where, as of 2018, she is a full professor of genetics.




Career


Skop is known for her work on Caenorhabditis elegans, a free-living worm, and mammalian tissue culture cells where she has studied the mechanisms that control cell division. Her early work was on the final stages of cell division in C. elegans, and she identified the proteins in the midbody that are involved in cell division. Her more recent work examines defects that could be caused by problems in the mammalian midbody, where she has shown that midbody is an organelle that harbors translationally active RNA.
As a faculty member, Skop guided the creation of a diversity committee within the genetics department in the College of Agriculture and Life Sciences at the University of Madison-Wisconsin and led the creation of their STEM Diversity Network.
Skop collaborated with undergraduate students Elif Kurt and Caitlin Marks to release Genetics Reflections: A coloring book in 2020.




Artistic career


Skop has curated a scientific art show at the International C. elegans meeting, the "Worm Art Show", and she worked with a Madison, Wisconsin artist, Angela Johnson to create an art installation called "Genetic Reflections".




Select publications


Jung GI, Londoño-Vásquez D, Park S, Skop AR, Balboula AZ, Schindler K. An oocyte meiotic midbody cap is required for developmental competence in mice. Nat Commun. 2023 Nov 16;14(1):7419. doi: 10.1038/s41467-023-43288-x. PMID: 37973997; PMCID: PMC10654508.
Park S, Patel SA, Torr EE, Dureke AN, McIntyre AM, Skop AR. A protocol for isolating and imaging large extracellular vesicles or midbody remnants from mammalian cell culture. STAR Protoc. 2023 Dec 15;4(4):102562. doi: 10.1016/j.xpro.2023.102562. Epub 2023 Sep 9. PMID: 37690025; PMCID: PMC10500451.
Park S, Dahn R, Kurt E, Presle A, VanDenHeuvel K, Moravec C, Jambhekar A, Olukoga O, Shepherd J, Echard A, Blower M, Skop AR. The mammalian midbody and midbody remnant are assembly sites for RNA and localized translation. Dev Cell. 2023 Oct 9;58(19):1917-1932.e6. doi: 10.1016/j.devcel.2023.07.009. Epub 2023 Aug 7. PMID: 37552987; PMCID: PMC10592306.
Skop, Ahna R.; Bergmann, Dominique; Mohler, William A.; White, John G. (2001-05-15). "Completion of cytokinesis in C. elegans requires a brefeldin A-sensitive membrane accumulation at the cleavage furrow apex". Current Biology. 11 (10): 735–746. Bibcode:2001CBio...11..735S. doi:10.1016/S0960-9822(01)00231-7. ISSN 0960-9822. PMC 3733387. PMID 11378383.
Skop, Ahna R.; Liu, Hongbin; Yates, John; Meyer, Barbara J.; Heald, Rebecca (2004-07-02). "Dissection of the Mammalian Midbody Proteome Reveals Conserved Cytokinesis Mechanisms". Science. 305 (5680): 61–66. Bibcode:2004Sci...305...61S. doi:10.1126/science.1097931. ISSN 0036-8075. PMC 3679889. PMID 15166316.
Skop, Ahna R.; White, John G. (1998-10-08). "The dynactin complex is required for cleavage plane specification in early Caenorhabditis elegans embryos". Current Biology. 8 (20): 1110–1117. Bibcode:1998CBio....8.1110S. doi:10.1016/S0960-9822(98)70465-8. ISSN 0960-9822. PMC 3690630. PMID 9778526.
Thompson, Heather M.; Skop, Ahna R.; Euteneuer, Ursula; Meyer, Barbara J.; McNiven, Mark A. (2002-12-23). "The Large GTPase Dynamin Associates with the Spindle Midzone and Is Required for Cytokinesis". Current Biology. 12 (24): 2111–2117. Bibcode:2002CBio...12.2111T. doi:10.1016/S0960-9822(02)01390-8. ISSN 0960-9822. PMC 3690653. PMID 12498685.
Otegui, Marisa S.; Verbrugghe, Koen J.; Skop, Ahna R. (2005-08-01). "Midbodies and phragmoplasts: analogous structures involved in cytokinesis". Trends in Cell Biology. 15 (8): 404–413. doi:10.1016/j.tcb.2005.06.003. ISSN 0962-8924. PMC 3677513. PMID 16009554.




Honors and awards


2006 Presidential Early Career Award for Scientists and Engineers, National Science Foundation
2009 Honorary Doctorate of Science, College of Saint Benedict,
2015 Kavli Fellowship, National Academy of Sciences
2016 Chancellor's Inclusive Excellence Award, University of Wisconsin-Madison
2018 Prize for Excellence in Inclusivity, American Society for Cell Biology, the first time this prize was given.
2019 IF/THEN Ambassador, American Association for the Advancement of Science
2019-20 Outstanding Women of Color, University of Winsconsin-Madison
2022 Vilas Faculty Mid-Career Investigator award, University of Wisconsin–Madison
2024 Fellows Award, Wisconsin Academy of Sciences, Arts & Letters




References






External links


Ahna Skop publications indexed by Google Scholar

Kata Kunci Pencarian:

• Ahna Skop
• IfThenSheCan
• Highlands High School (Fort Thomas, Kentucky)
• Presidential Early Career Award for Scientists and Engineers
• John G. White (biologist)
• Phragmoplast
• Halperin-Birk syndrome