- Source: AKR1C1
Aldo-keto reductase family 1 member C1 also known as 20α-hydroxysteroid dehydrogenase, 3α-hydroxysteroid dehydrogenase, and dihydrodiol dehydrogenase 1/2 is an enzyme that in humans is encoded by the AKR1C1 gene.
Superfamily of enzymes
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This specific enzyme, AKR1C1, among other reactions, catalyzes the reduction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. The AKR1C1 gene shares high sequence identity with three other gene members, and is clustered with those three genes at chromosome 10p15-p14.
Isozymes of aldo-keto reductase family 1 member C
References
See also
3α-Hydroxysteroid dehydrogenase
External links
Human AKR1C1 genome location and AKR1C1 gene details page in the UCSC Genome Browser.
Human C9 genome location and C9 gene details page in the UCSC Genome Browser.
Further reading
Kata Kunci Pencarian:
- Daftar gen penyandi protein pada manusia/1
- AKR1C1
- 5α-Dihydroprogesterone
- 3α-Hydroxysteroid dehydrogenase
- Dydrogesterone
- Lumateperone
- Progesterone
- AKR1
- 20α-Dihydroprogesterone
- 20alpha-hydroxysteroid dehydrogenase
- List of human protein-coding genes 1
