• Source: Alpha-1B adrenergic receptor

The alpha-1B adrenergic receptor (α1B-adrenoreceptor), also known as ADRA1B, is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it. The crystal structure of the α1B-adrenergic receptor has been determined in complex with the inverse agonist (+)-cyclazosin.




Receptor


There are 3 alpha-1 adrenergic receptor subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. They activate mitogenic responses and regulate growth and proliferation of many cells.




Gene


This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region.




Ligands


Antagonists
L-765,314
Risperidone
Brexpiprazole




Interactions


Alpha-1B adrenergic receptor has been shown to interact with AP2M1. A role in regulation of dopaminergic neurotransmission has also been suggested.




See also


Adrenergic receptor




References






External links


Human ADRA1B genome location and ADRA1B gene details page in the UCSC Genome Browser.




Further reading

Kata Kunci Pencarian:

• Prazosin
• Alpha-1B adrenergic receptor
• Alpha-2A adrenergic receptor
• Alpha-1A adrenergic receptor
• Alpha-2 adrenergic receptor
• Alpha-1 adrenergic receptor
• Alpha-2C adrenergic receptor
• Alpha-1D adrenergic receptor
• Adrenergic receptor
• 1B
• Alpha-1 blocker