• Source: Alpha-1D adrenergic receptor

The alpha-1D adrenergic receptor (α1D adrenoreceptor), also known as ADRA1D, is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it.




Receptor


There are 3 alpha-1 adrenergic receptor subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. They activate mitogenic responses and regulate growth and proliferation of many cells.




Gene


This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region.




Ligands


Many α1 receptor ligands are non-selective for receptor subtypes.

Antagonists
A-315456
BMY 7378 (also α2C antagonist)
Domesticine
Cyclazosin (slight α1C selectivity)
Tamsulosin (roughly equal affinity for α1A)




See also


Adrenergic receptor




References






Further reading






External links


Human ADRA1A genome location and ADRA1A gene details page in the UCSC Genome Browser.
Human ADRA1D genome location and ADRA1D gene details page in the UCSC Genome Browser.

Kata Kunci Pencarian:

• Prazosin
• Alpha-1D adrenergic receptor
• 1D
• Alpha-1A adrenergic receptor
• Alpha-2C adrenergic receptor
• Alpha-1B adrenergic receptor
• Alpha-1 blocker
• Prazosin
• Oxymetazoline
• Ryanodine receptor
• Lisuride