- Source: Bombesin
Bombesin is a 14-amino acid peptide originally isolated from the skin of the European fire-bellied toad (Bombina bombina) by Vittorio Erspamer et al. and named after its source. It has two known homologs in mammals called neuromedin B and gastrin-releasing peptide. It stimulates gastrin release from G cells. It activates three different G-protein-coupled receptors known as BBR1, -2, and -3. It also activates these receptors in the brain. Together with cholecystokinin, it is the second major source of negative feedback signals that stop eating behaviour.
Bombesin is also a tumor marker for small cell carcinoma of lung, gastric cancer, pancreatic cancer, and neuroblastoma.
Receptors
The anuran BB4 receptor homologue is termed frog BB4 (fBB4). Iwabuchi et al. 2003 discovered a chicken (Gallus domesticus) receptor which is homologous to both the mammalian BB3 and fBB4 and so they named it chBRS-3.5.
Effects
Erspamer 1988 finds bombesin has a similar effect on the chicken to ranatensin, unreliably increasing or decreasing blood pressure.
See also
Gastrin-releasing peptide
Neuromedin B
Neuromedin U
References
Kata Kunci Pencarian:
- Endometriosis
- Daftar jenis sel pada tubuh manusia
- Reseptor terhubung protein G
- Gastrin
- Bombesin
- Bombesin receptor
- Gastrin-releasing peptide
- Bombesin-like receptor 3
- Bombesin-like peptides
- Oriental fire-bellied toad
- Gastrin-releasing peptide receptor
- G cell
- Kuwanon G
- Fire-bellied toad
