- Source: Columbamine O-methyltransferase
In enzymology, a columbamine O-methyltransferase (EC 2.1.1.118) is an enzyme that catalyzes the chemical reaction
S-adenosyl-L-methionine + columbamine
⇌
{\displaystyle \rightleftharpoons }
S-adenosyl-L-homocysteine + palmatine
Thus, the two substrates of this enzyme are S-adenosyl methionine and columbamine, whereas its two products are S-adenosylhomocysteine and palmatine.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:columbamine O-methyltransferase. This enzyme participates in alkaloid biosynthesis i.
References
Rueffer M, Amann M, Zenk MH (1986). "S-Adenosyl-L-methionine:columbamine O-methyltransferase, a compartmentalized enzyme in protoberberine biosynthesis". Plant Cell Reports. 3: 182–185.
