• Source: DNA-SCARS

DNA-SCARS (short for DNA segments with chromatin alterations reinforcing senescence) are nuclear substructures with persistent DNA damage and DNA damage response proteins found in senescent cells. DNA-SCARS are associated with PML nuclear bodies and the accumulation of activated ATM, ATR, CHK2 and p53 proteins. DNA-SCARS lack most of the characteristics of transient, reversible DNA damage foci, such as single-stranded DNA, active DNA synthesis, and DNA repair proteins RPA and RAD51. Telomere dysfunction-induced foci (TIF) are generally associated with DNA-SCARS.
Together with senescence-associated heterochromatin foci (SAHF), DNA-SCARS are one of the most prevalent nuclear markers of cellular senescence.




History


DNA-SCARS were discovered by Judith Campisi and colleagues, who first described them in 2011, although most of their characteristics were previously known.




References

Kata Kunci Pencarian:

• Reaksi berantai polimerase
• Logan (film)
• Virus dalam sejarah manusia
• Black Panther (film)
• Paus sei
• DNA-SCARS
• Cellular senescence
• No-SCAR genome editing
• Murder of Joseph Augustus Zarelli
• Neoplasm
• DNA Doe Project
• Artificial gene synthesis
• BioBrick
• Zodiac Killer suspects
• Fibrosis