• Source: DUSP16

Dual specificity protein phosphatase 16 is an enzyme that in humans is encoded by the DUSP16 gene.
The activation of mitogen-activated protein kinase (MAPK) cascades transduces various extracellular signals to the nucleus to induce gene expression, cell proliferation, differentiation, cell cycle arrest, and apoptosis. For full activation of MAPKs, dual-specificity kinases phosphorylate both threonine and tyrosine residues in MAPK TXY motifs. MKPs are dual-specificity phosphatases that dephosphorylate the TXY motif, thereby negatively regulating MAPK activity.[supplied by OMIM]




Interactions


DUSP16 has been shown to interact with MAPK14 and MAPK8IP1.




References






Further reading






External links


PDBe-KB provides an overview of all the structure information available in the PDB for Human Dual specificity protein phosphatase 16

Kata Kunci Pencarian:

• Daftar gen penyandi protein pada manusia/1
• DUSP16
• List of human protein-coding genes 1
• Protein phosphatase
• Rhodanese
• MAPK phosphatase
• Ataxia–telangiectasia
• MAPK8IP1
• MAPK14