• Source: Ezrin

Ezrin also known as cytovillin or villin-2 is a protein that in humans is encoded by the EZR gene.




Structure


The N-terminus of ezrin contains a FERM domain which is further subdivided into three subdomains. The C-terminus contains an ERM domain.




Function


The cytoplasmic peripheral protein encoded by this gene can be phosphorylated by protein-tyrosine kinase in microvilli and is a member of the ERM protein family. This protein serves as a linker between plasma membrane and actin cytoskeleton. It plays a key role in cell surface structure adhesion, migration, and organization.
The N-terminal domain (also called FERM domain) binds sodium-hydrogen exchanger regulatory factor (NHERF) protein (involving long-range allostery). This binding can happen only when ezrin is in its active state. The activation of ezrin occurs in synergism of the two factors: 1) binding of the N-terminal domain to phosphatidylinositol(4,5)bis-phosphate (PIP2) and 2) phosphorylation of threonine T567 in the C-terminal domain. Binding to actin filaments (via C-terminal) and to membrane proteins (via N-terminal) stabilizes the protein's conformation in its active mode. The membrane proteins like CD44 and ICAM-2 are indirect binding partners of ezrin, while EBP50 (ERM binding protein 50) can associate with ezrin directly.




Interactions


VIL2 has been shown to interact with:




References






Further reading

Kata Kunci Pencarian:

• Revenge
• A Momentary Lapse of Reason
• Wavin' Flag
• Rumpun suku bangsa Austronesia
• The Division Bell
• The Wall (album)
• Get Your Wings
• Pink Floyd
• Thirty Seconds to Mars
• Degradasi polimer
• Bob Ezrin
• Ezrin
• The Wall
• Music from "The Elder"
• Destroyer (Kiss album)
• Welcome to My Nightmare
• =1
• A Momentary Lapse of Reason
• Strays (Jane's Addiction album)
• Another Brick in the Wall