- Source: F-box protein 40
F-box protein 40 is a protein that in humans is encoded by the FBXO40 gene. Fbxo40 induces ubiquitination of IRS1, thus limiting activity of IGF1 signaling (Shi et al, 2011).
Function
Members of the F-box protein family, such as FBXO40, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains.
Fbxo40 in particular engages a unique substrate, IRS1, which is a protein in the IGF1 signaling pathway. In this way, Fbxo40 causes ubiquitination and degradation of IRS1, blocking further signaling downstream of the IGF1 receptor.
References
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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- F-box protein 40
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- FOX proteins
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