• Source: Farnesol

Farnesol is a natural 15-carbon organic compound which is an acyclic sesquiterpene alcohol. Under standard conditions, it is a colorless liquid. It is hydrophobic, and thus insoluble in water, but miscible with oils. As the pyrophosphate ester, farnesol is a precursor to many terpenes and terpenoids.




Uses


Farnesol is present in many essential oils such as citronella, neroli, cyclamen, lemon grass, tuberose, rose, musk, balsam, and tolu. It is used in perfumery to emphasize the odors of sweet, floral perfumes. It enhances perfume scent by acting as a co-solvent that regulates the volatility of the odorants. It is especially used in lilac perfumes. Farnesol and its ester derivatives are important precursors for a variety of other compounds used as fragrances and vitamins.




= Cosmetics

=
Farnesol is used as a deodorant in cosmetic products. Farnesol is subject to restrictions on its use in perfumery, because some people may become sensitised to it.




Natural source and synthesis






= In nature

=
Pyrophosphate-activated derivatives of farnesol are the building blocks of possibly all acyclic sesquiterpenoids. These compounds are doubled to form 30-carbon squalene, which is the precursor for steroids in plants, animals, and fungi.
Farnesyl pyrophosphate is produced from the reaction of geranyl pyrophosphate and isopentenyl pyrophosphate. Farnesyl pyrophosphate is the precursor to farnesol and farnesene.

Farnesol is used by the fungus Candida albicans as a quorum sensing molecule that inhibits filamentation.




= Commercial production

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Obtaining farnesol from natural sources is uneconomical. In industry, farnesol is produced from linalool.




History of the name


Farnesol was named (ca. 1900–1905) after the Farnese acacia tree (Vachellia farnesiana), since the flowers from the tree were the commercial source of the floral essence in which the chemical was identified. This particular acacia species, in turn, is named after Cardinal Odoardo Farnese (1573–1626) of the Italian Farnese family who (from 1550 though the 17th century) maintained some of the first private European botanical gardens in the Farnese Gardens in Rome. The addition of the -ol suffix implies an alcohol. The plant itself was brought to the Farnese gardens from the Caribbean and Central America, where it originates.




See also


Farnesylation
Farnesene
Farnesyl pyrophosphate
Geranylgeraniol
Nerolidol




References

Kata Kunci Pencarian:

• Temporin
• Indometasin farnesil
• Terpena
• Biofilm
• Beri arar
• Balsam Peru
• Protein urin mayor
• Farnesol
• Farnesol dehydrogenase
• Farnesol 2-isomerase
• Neroli
• Prenylation
• Artemisia pallens
• Temporin
• Chamomile
• Methanol
• Juvenile hormone