• Source: Frizzled-3

3/info/frizzled" target="_blank">Frizzled-3 (Fz-3) is a protein that in humans is encoded by the FZD3 gene.




Function


This gene is a member of the 3/info/frizzled" target="_blank">frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most 3/info/frizzled" target="_blank">frizzled receptors are coupled to the beta-catenin canonical signaling pathway. It may play a role in mammalian hair follicle development.
The function of this gene is largely derived from mouse studies. Fzd3 in the mouse functions through planar cell polarity signaling instead of the canonical Wnt/beta-catenin pathway. Fzd3 controls axon growth and guidance in the mouse nervous system, and migration of neural crest cells.




See also


3/info/frizzled" target="_blank">Frizzled




References






Further reading






External links


"3/info/frizzled" target="_blank">Frizzled Receptors: FZD3". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2014-09-03. Retrieved 2008-12-04.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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