- Source: Fumarate reductase
Fumarate reductase is the enzyme that converts fumarate to succinate, and is important in microbial metabolism as a part of anaerobic respiration. The catalyzed reaction is:
succinate + acceptor <=> fumarate + reduced acceptor
Fumarate reductases can be divided into two classes depending on the electron acceptor:
Fumarate reductase (NADH) (EC 1.3.1.6)
The enzyme is monomeric and soluble, and can reduce fumarate independently from the electron transport chain. Fumarate reductase is absent from all mammalian cells.
Fumarate reductase (quinol) (EC 1.3.5.4)
The membrane-bound enzyme covalently linked to flavin cofactors, which is composed of 3 or 4 subunits, transfers electrons from a quinol to fumarate. This class of enzyme is thus involved in the production of ATP by oxidative phosphorylation.
References
External links
Fumarate+Reductase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Kata Kunci Pencarian:
- Fumarat reduktase
- Teori kemiosmotik
- Fosforilasi oksidatif
- Fumarate reductase
- Fumarate reductase (quinol)
- Fumarate reductase (NADH)
- Oxidative phosphorylation
- Fumaric acid
- FNR regulon
- Succinate dehydrogenase
- Electron transport chain
- Coenzyme B
- Biological carbon fixation
