- Source: Glycosylceramidase
The enzyme glycosylceramidase (EC 3.2.1.62) catalyzes the following chemical reaction:
glycosyl-N-acylsphingosine + H2O
⇌
{\displaystyle \rightleftharpoons }
N-acylsphingosine + a sugar
It belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is glycosyl-N-acylsphingosine glycohydrolase. Other names in common use include phlorizin hydrolase, phloretin-glucosidase, glycosyl ceramide glycosylhydrolase, cerebrosidase, phloridzin β-glucosidase, lactase-phlorizin hydrolase, and phloridzin glucosidase.
References
Leese HJ, Semenza G (1973). "On the identity between the small intestinal enzymes phlorizin hydrolase and glycosylceramidase". J. Biol. Chem. 248 (23): 8170–3. PMID 4752949.
Lorenz-Meyer H, Blum AL, Haemmerli HP, Semenza G (1972). "A second enzyme defect in acquired lactase deficiency: lack of small-intestinal phlorizin-hydrolase". Eur. J. Clin. Invest. 2 (5): 326–31. doi:10.1111/j.1365-2362.1972.tb00658.x. PMID 5082068.
Malathi P, Crane RK (1969). "Phlorizin hydrolase: a β-glucosidase of hamster intestinal brush border membrane". Biochim. Biophys. Acta. 173 (2): 245–56. doi:10.1016/0005-2736(69)90108-4. PMID 5774775.