• Source: Growth factor

A growth factor is a naturally occurring substance capable of stimulating cell proliferation, wound healing, and occasionally cellular differentiation. Usually it is a secreted protein or a steroid hormone. Growth factors are important for regulating a variety of cellular processes.
Growth factors typically act as signaling molecules between cells. Examples are cytokines and hormones that bind to specific receptors on the surface of their target cells.
They often promote cell differentiation and maturation, which varies between growth factors. For example, epidermal growth factor (EGF) enhances osteogenic differentiation (osteogenesis or bone formation), while fibroblast growth factors and vascular endothelial growth factors stimulate blood vessel differentiation (angiogenesis).




Comparison to cytokines


Growth factor is sometimes used interchangeably among scientists with the term cytokine. Historically, cytokines were associated with hematopoietic (blood and lymph forming) cells and immune system cells (e.g., lymphocytes and tissue cells from spleen, thymus, and lymph nodes). For the circulatory system and bone marrow in which cells can occur in a liquid suspension and not bound up in solid tissue, it makes sense for them to communicate by soluble, circulating protein molecules. However, as different lines of research converged, it became clear that some of the same signaling proteins which the hematopoietic and immune systems use were also being used by all sorts of other cells and tissues, during development and in the mature organism.
While growth factor implies a positive effect on cell proliferation, cytokine is a neutral term with respect to whether a molecule affects proliferation. While some cytokines can be growth factors, such as G-CSF and GM-CSF, others have an inhibitory effect on cell growth or cell proliferation. Some cytokines, such as Fas ligand, are used as "death" signals; they cause target cells to undergo programmed cell death or apoptosis.
The nerve growth factor (NGF) was first discovered by Rita Levi-Montalcini, which won her a Nobel Prize in Physiology or Medicine.




List of classes



Individual growth factor proteins tend to occur as members of larger families of structurally and evolutionarily related proteins. There are many families, some of which are listed below:

Adrenomedullin (AM)
Angiopoietin (Ang)
Autocrine motility factor
Bone morphogenetic proteins (BMPs)
Ciliary neurotrophic factor family
Ciliary neurotrophic factor (CNTF)
Leukemia inhibitory factor (LIF)
Interleukin-6 (IL-6)
Colony-stimulating factors
Macrophage colony-stimulating factor (M-CSF)
Granulocyte colony-stimulating factor (G-CSF)
Granulocyte macrophage colony-stimulating factor (GM-CSF)
Epidermal growth factor (EGF)
Ephrins
Ephrin A1
Ephrin A2
Ephrin A3
Ephrin A4
Ephrin A5
Ephrin B1
Ephrin B2
Ephrin B3
Erythropoietin (EPO)
Fibroblast growth factor (FGF)
Fibroblast growth factor 1(FGF1)
Fibroblast growth factor 2(FGF2)
Fibroblast growth factor 3(FGF3)
Fibroblast growth factor 4(FGF4)
Fibroblast growth factor 5(FGF5)
Fibroblast growth factor 6(FGF6)
Fibroblast growth factor 7(FGF7)
Fibroblast growth factor 8(FGF8)
Fibroblast growth factor 9(FGF9)
Fibroblast growth factor 10(FGF10)
Fibroblast growth factor 11(FGF11)
Fibroblast growth factor 12(FGF12)
Fibroblast growth factor 13(FGF13)
Fibroblast growth factor 14(FGF14)
Fibroblast growth factor 15(FGF15)
Fibroblast growth factor 16(FGF16)
Fibroblast growth factor 17(FGF17)
Fibroblast growth factor 18(FGF18)
Fibroblast growth factor 19(FGF19)
Fibroblast growth factor 20(FGF20)
Fibroblast growth factor 21(FGF21)
Fibroblast growth factor 22(FGF22)
Fibroblast growth factor 23(FGF23)
Foetal Bovine Somatotrophin (FBS)
GDNF family of ligands
Glial cell line-derived neurotrophic factor (GDNF)
Neurturin
Persephin
Artemin
Growth differentiation factor-9 (GDF9)
Hepatocyte growth factor (HGF)
Hepatoma-derived growth factor (HDGF)
Insulin
Insulin-like growth factors
Insulin-like growth factor-1 (IGF-1)
Insulin-like growth factor-2 (IGF-2)
Interleukins
IL-1- Cofactor for IL-3 and IL-6. Activates T cells.
IL-2 – T-cell growth factor. Stimulates IL-1 synthesis. Activates B-cells and NK cells.
IL-3 – Stimulates production of all non-lymphoid cells.
IL-4 – Growth factor for activated B cells, resting T cells, and mast cells.
IL-5 – Induces differentiation of activated B cells and eosinophils.
IL-6 – Stimulates Ig synthesis. Growth factor for plasma cells.
IL-7 – Growth factor for pre-B cells.
Keratinocyte growth factor (KGF)
Migration-stimulating factor (MSF)
Macrophage-stimulating protein (MSP), also known as hepatocyte growth factor-like protein (HGFLP)
Myostatin (GDF-8)
Neuregulins
Neuregulin 1 (NRG1)
Neuregulin 2 (NRG2)
Neuregulin 3 (NRG3)
Neuregulin 4 (NRG4)
Neurotrophins
Brain-derived neurotrophic factor (BDNF)
Nerve growth factor (NGF)
Neurotrophin-3 (NT-3)
Neurotrophin-4 (NT-4)
Placental growth factor (PGF)
Platelet-derived growth factor (PDGF)
Renalase (RNLS) – Anti-apoptotic survival factor
T-cell growth factor (TCGF)
Thrombopoietin (TPO)
Transforming growth factors
Transforming growth factor alpha (TGF-α)
Transforming growth factor beta (TGF-β)
Tumor necrosis factor-alpha (TNF-α)
Vascular endothelial growth factor (VEGF)




In platelets


The alpha granules in blood platelets contain growth factors PDGF, IGF-1, EGF, and TGF-β which begin healing of wounds by attracting and activating macrophages, fibroblasts, and endothelial cells.




Uses in medicine


For the last two decades, growth factors have been increasingly used in the treatment of hematologic and oncologic diseases and cardiovascular diseases such as:

skin wound healing and regeneration of other tissues such as bone (PDGF-BB)
neutropenia
myelodysplastic syndrome (MDS)
leukemias
aplastic anaemia
bone marrow transplantation
angiogenesis for cardiovascular diseases




See also


Angiogenesis
Bone growth factor
Cytokine
Growth factor receptor
Human Genome Organisation
Mitogen
Neurotrophic factor
Receptor (biochemistry)
Signal transduction
Wound healing § Overview of involved growth factors




References






External links


Growth+Factors at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
FGF5 in Hair Tonic Products
FGF1 in Cosmetic Products

Kata Kunci Pencarian:

• Jaringan granulasi
• Faktor pertumbuhan perubahan
• Interleukin-6
• TGF beta 1
• Faktor pertumbuhan hepatosit
• Protein Kinase B
• Faktor pertumbuhan endotel vaskular
• Faktor pertumbuhan saraf
• Faktor pertumbuhan platelet turunan
• Faktor pertumbuhan
• Growth factor
• Epidermal growth factor
• Insulin-like growth factor 1
• Epidermal growth factor receptor
• Vascular endothelial growth factor
• Nerve growth factor
• Fibroblast growth factor
• Hepatocyte growth factor
• Transforming growth factor
• Platelet-derived growth factor