• Source: Hydroxymethylglutaryl-CoA reductase (NADPH)

In enzymology, a hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.1.34) is an enzyme that catalyzes the chemical reaction

(R)-mevalonate + CoA + 2 NADP+



⇌


{\displaystyle \rightleftharpoons }

(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
The 3 substrates of this enzyme are (R)-mevalonate, CoA, and NADP+, whereas its 3 products are (S)-3-hydroxy-3-methylglutaryl-CoA, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, to be specific those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. This enzyme participates in biosynthesis of steroids including cholesterol. The statin class of anticholesterol drugs act through inhibiting this enzyme.




Nomenclature


The systematic name of this enzyme class is (R)-mevalonate:NADP+ oxidoreductase (CoA-acylating). Other names in common use include:

hydroxymethylglutaryl coenzyme A reductase (reduced nicotinamide adenine dinucleotide phosphate)
3-hydroxy-3-methylglutaryl-CoA reductase
β-hydroxy-β-methylglutaryl coenzyme A reductase
hydroxymethylglutaryl CoA reductase (NADPH)
S-3-hydroxy-3-methylglutaryl-CoA reductase
NADPH-hydroxymethylglutaryl-CoA reductase
HMGCoA reductase-mevalonate:NADP-oxidoreductase (acetylating-CoA)
3-hydroxy-3-methylglutaryl CoA reductase (NADPH)
hydroxymethylglutaryl-CoA reductase (NADPH2).




Structural studies


As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes 1DQ8, 1DQ9, 1DQA, 1HW8, 1HW9, 1HWI, 1HWJ, 1HWK, 1HWL, 2Q1L, 2Q6B, and 2Q6C.




References

Kata Kunci Pencarian:

• HMG-CoA reductase
• Hydroxymethylglutaryl-CoA reductase (NADPH)
• AMP-activated protein kinase
• (hydroxymethylglutaryl-CoA reductase (NADPH))-phosphatase
• HMG-CoA
• Dephospho-(reductase kinase) kinase
• List of EC numbers (EC 1)
• Mupirocin
• PRKAA2
• List of EC numbers (EC 2)