- Source: Ibogamine
Ibogamine is an anti-convulsant, anti-addictive, CNS stimulant alkaloid found in Tabernanthe iboga and Crepe Jasmine (Tabernaemontana divaricata). Basic research related to how addiction affects the brain has used this chemical.
Ibogamine persistently reduced the self-administration of cocaine and morphine in rats. The same study found that ibogamine (40 mg/kg) and coronaridine (40 mg/kg) did not produce "any tremor effects in rats that differ significantly from saline control". While the related alkaloids ibogaine (20–40 mg/kg), harmaline (10–40 mg/kg) and desethylcoronaridine (10–40 mg/kg) were "obviously tremorgenic".
Chemistry
= Synthesis
=Ibogamine can be prepared from one-step demethoxycarbonylation process through coronaridine.
Pharmacology
Like ibogaine, it has seems to have similar pharmacology. It has effects on KOR, NMDAR, nAChR and serotonin sites. It also inhibits acetylcholinesterase and butyrylcholinesterase.
See also
Coronaridine
Ibogaine
Ibogaline
Tabernanthine
Voacangine
Harmaline
References
Kata Kunci Pencarian:
- Ibogamine
- Voacangine
- Ibogaine
- Tabernaemontana divaricata
- Tabernanthine
- List of psychoactive plants, fungi, and animals
- Ketamine
- Alcohol (drug)
- Iboga-type alkaloid
- MDMA
