- Source: Integrin alpha X
CD11c, also known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a gene that encodes for CD11c .
CD11c is an integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles.
CD11c is a type I transmembrane protein found at high levels on most human dendritic cells, but also on monocytes, macrophages, neutrophils, and some B cells that induces cellular activation and helps trigger neutrophil respiratory burst; expressed in hairy cell leukemias, acute nonlymphocytic leukemias, and some B-cell chronic lymphocytic leukemias.
See also
Integrin
References
Further reading
External links
CD11c+Antigens at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Mouse CD Antigen Chart
Human CD Antigen Chart
ITGAX Info with links in the Cell Migration Gateway Archived 2014-12-11 at the Wayback Machine
Human ITGAX genome location and ITGAX gene details page in the UCSC Genome Browser.
Overview of all the structural information available in the PDB for UniProt: P20702 (Integrin alpha-X) at the PDBe-KB.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Kata Kunci Pencarian:
- Sklerosis multipel
- Landak laut
- Kanker
- Kanker payudara
- Integrin alpha X
- Integrin alpha M
- Integrin alpha L
- Integrin
- Integrin alpha 2b
- Integrin alpha 4
- Integrin alpha 7
- Integrin beta 1
- Integrin alpha 3
- Integrin alpha 8
