• Source: L-iditol 2-dehydrogenase

In enzymology, a L-iditol 2-dehydrogenase (EC 1.1.1.14) is an enzyme that catalyzes the chemical reaction

L-iditol + NAD+ ⇌ L-sorbose + NADH + H+
Thus, the two substrates of this enzyme are L-iditol and NAD+, whereas its 3 products are L-sorbose, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-iditol:NAD+ 2-oxidoreductase. Other names in common use include polyol dehydrogenase, sorbitol dehydrogenase, L-iditol:NAD+ 5-oxidoreductase, L-iditol (sorbitol) dehydrogenase, glucitol dehydrogenase, L-iditol:NAD+ oxidoreductase, NAD+-dependent sorbitol dehydrogenase, NAD+-dependent sorbitol dehydrogenase, and NAD+-sorbitol dehydrogenase. This enzyme participates in fructose and mannose metabolism.




Structural studies


As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1K2W, 1PL6, 1PL7, and 1PL8.




References



Bailey JP, Renz C, McGuinness ET (1981). "Sorbitol dehydrogenase from horse liver: purification, characterization and comparative properties". Comp. Biochem. Physiol. 69B: 909–914.
Burnell JN, Holmes RS (1983). "Purification and properties of sorbitol dehydrogenase from mouse liver". Int. J. Biochem. 15 (4): 507–11. doi:10.1016/0020-711X(83)90124-6. PMID 6852349.
Leissing N, McGuinness ET (1978). "Rapid affinity purification and properties of rat liver sorbitol dehydrogenase". Biochim. Biophys. Acta. 524 (2): 254–61. doi:10.1016/0005-2744(78)90162-6. PMID 667078.
Negm FB, Loescher WH (1979). "Detection and Characterization of Sorbitol Dehydrogenase from Apple Callus Tissue". Plant Physiol. 64 (1): 69–73. doi:10.1104/pp.64.1.69. PMC 543026. PMID 16660917.
O'Brien MM, Schofield PJ, Edwards MR (1983). "Polyol-pathway enzymes of human brain. Partial purification and properties of sorbitol dehydrogenase". Biochem. J. 211 (1): 81–90. doi:10.1042/bj2110081. PMC 1154331. PMID 6870831.

Kata Kunci Pencarian:

• L-iditol 2-dehydrogenase
• Iditol
• SORD
• List of EC numbers (EC 1)
• Isopropyl alcohol
• 2-Methyl-1-butanol
• Sorbitol
• 1-Butanol
• List of MeSH codes (D08)
• Xylitol