- Source: Lipid-phosphate phosphatase
The enzyme lipid-phosphate phosphatase (EC 3.1.3.76) catalyzes the reaction
(9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate + H2O
⇌
{\displaystyle \rightleftharpoons }
(9S,10S)-9,10-dihydroxyoctadecanoate + phosphate
This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name is (9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate phosphohydrolase. Other names in common use include hydroxy fatty acid phosphatase, dihydroxy fatty acid phosphatase, hydroxy lipid phosphatase, sEH (ambiguous), and soluble epoxide hydrolase (ambiguous).
See also
Epoxide hydrolase 2
References
Morisseau C, Hammock BD (2005). "Epoxide hydrolases: mechanisms, inhibitor designs, and biological roles". Annu. Rev. Pharmacol. Toxicol. 45: 311–33. doi:10.1146/annurev.pharmtox.45.120403.095920. PMID 15822179.
Tran KL, Aronov PA, Tanaka H, Newman JW, Hammock BD, Morisseau C (2005). "Lipid sulfates and sulfonates are allosteric competitive inhibitors of the N-terminal phosphatase activity of the mammalian soluble epoxide hydrolase". Biochemistry. 44 (36): 12179–87. doi:10.1021/bi050842g. PMC 1473036. PMID 16142916.
Newman JW, Morisseau C, Hammock BD (2005). "Epoxide hydrolases: their roles and interactions with lipid metabolism". Prog. Lipid Res. 44 (1): 1–51. doi:10.1016/j.plipres.2004.10.001. PMID 15748653.
Srivastava PK, Sharma VK, Kalonia DS, Grant DF (2004). "Polymorphisms in human soluble epoxide hydrolase: effects on enzyme activity, enzyme stability, and quaternary structure". Arch. Biochem. Biophys. 427 (2): 164–9. doi:10.1016/j.abb.2004.05.003. PMID 15196990.
Gomez GA, Morisseau C, Hammock BD, Christianson DW (2004). "Structure of human epoxide hydrolase reveals mechanistic inferences on bifunctional catalysis in epoxide and phosphate ester hydrolysis". Biochemistry. 43 (16): 4716–23. doi:10.1021/bi036189j. PMID 15096040.
Kata Kunci Pencarian:
- Metabolisme
- PTEN
- Reseptor terhubung protein G
- Lipid-phosphate phosphatase
- Phosphatidate phosphatase
- Alkaline phosphatase
- Epoxide hydrolase 2
- Nicotinamide adenine dinucleotide phosphate
- Phosphatidic acid phosphatase 2c
- PPAP2B
- PPAP2A
- Glucose 6-phosphatase
- Protein phosphatase
