• Source: Mean platelet volume

Mean platelet volume (MPV) is a machine-calculated measurement of the average size of platelets found in blood and is typically included in blood tests as part of the CBC. Since the average platelet size is larger when the body is producing increased numbers of platelets, the MPV test results can be used to make inferences about platelet production in bone marrow or platelet destruction problems.
An increased mean platelet volume (MPV) increases the risk to suffer a heart disease
MPV may be higher when there is destruction of platelets. This may be seen in immune thrombocytopenic purpura (ITP), myeloproliferative diseases and Bernard–Soulier syndrome. It may also be related to pre-eclampsia and recovery from transient hypoplasia.
Abnormally low MPV values may correlate with thrombocytopenia when it is due to impaired production of megakaryocytes in the bone marrow, such as in aplastic anemia. A low MPV may indicate inflammatory bowel disease (IBD), such as Crohn's disease and ulcerative colitis. A high MPV is also a bad prognostic marker in patients with sepsis or septic shock. In addition, low MPV may correlate with abnormally small platelet size, sometimes a symptom of a spectrum referred to as Wiskott–Aldrich syndrome (WAS), caused by a genetic mutation of the WAS gene.
Sample for MPV testing is obtained in a Lavender-Top EDTA tube. A typical range of platelet volumes is 7.2 - 11.7 fL (femtolitre), equivalent to spheres 2.65 to 2.9 μm in diameter.




Conditions associated with altered MPV






= Decreased MPV

=
Cytotoxic chemotherapy
Hypersplenism
Reactive thrombocytosis
Iron-deficiency anemia
Gilbert's syndrome
Acquired Immunodeficiency Syndrome (AIDS)
Wiskott–Aldrich syndrome
X linked thrombocytopenia
Crohn's disease
Ulcerative colitis
Aplastic anemia
Megaloblastic anemia




= Increased MPV

=
Immune thrombocytopenia
Disseminated intravascular coagulation
Myeloproliferative disorders
Administration of erythropoietin / thrombopoietin
Recovery from transient hypoplasia
Gray platelet syndrome
GATA-1 mutation
vWD Type 2B
Platelet Type vWD
Paris-Trousseau syndrome
Mediterranean macrothrombocytopenia
Bernard–Soulier syndrome
MYH9-related disorders
21q11 deletion syndrome
Chronic myelogenous leukemia
Post-splenectomy
Vasculitis
Diabetes mellitus
Pre-eclampsia
Chronic kidney disease
Respiratory diseases
Thrombocytopenia secondary to sepsis
Hyperthyroidism
Hypothyroidism
Myocardial infarction
Artificial heart valves
Massive hemorrhage




Inherited thrombocytopenia with normal MPV


ATRUS Syndrome
Thrombocytopenia 2 (THC2)
Congenital amegakaryocytic thrombocytopenia
TAR syndrome
Familial platelet disorder with predisposition to AML




References






Further reading

Kata Kunci Pencarian:

• Mean platelet volume
• Giant platelet disorder
• Complete blood count
• Reference ranges for blood tests
• Harris platelet syndrome
• MPV
• Gilbert's syndrome
• Coronary artery ectasia
• Anisocytosis
• List of medical abbreviations: M