• Source: Melatonin receptor 1A

Melatonin receptor type 1A is a protein that in humans is encoded by the MTNR1A gene.




Function


This gene encodes the MT1 protein, one of two high-affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G protein-coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin.




Ligands


Melatonin – full agonist
Afobazole – agonist
Agomelatine – agonist




See also


Melatonin receptor
Discovery and development of melatonin receptor agonists




References






Further reading

Kata Kunci Pencarian:

• Melatonin receptor 1A
• Melatonin receptor
• 1A
• 5-HT1A receptor
• Vasopressin receptor 1A
• Melatonin receptor 1C
• Melatonin receptor 1B
• Alpha-1A adrenergic receptor
• G protein-coupled receptor
• Rhodopsin-like receptors