- Source: Melatonin receptor 1B
Melatonin receptor 1B, also known as MTNR1B, is a protein that in humans is encoded by the MTNR1B gene.
Function
This gene encodes the MT2 protein, one of two high-affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain; however, this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin. Besides the brain and retina this receptor is expressed on the bone forming cells where it regulates their function in depositing bone.
Clinical significance
Several studies have identified MTNR1B receptor mutations that are associated with increased average blood sugar level and around a 20 percent elevated risk of developing type 2 diabetes. MTNR1B mRNA is expressed in human islets, and immunocytochemistry confirms that it is primarily localized in beta cells in islets.
Ligands
The following MT2R ligands have selectivity over MT1R:
Compound 3d: antagonist with sub-nM affinity
Compound 18f: antagonist and compound 18g partial agonist: sub-nM affinity, >100-fold selectivity over MT1
Compound 14: antagonist
Compound 13: agonist
See also
Melatonin receptor
Discovery and development of melatonin receptor agonists
References
Further reading
External links
"Melatonin Receptors: MT2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-05.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Kata Kunci Pencarian:
- Melatonin receptor 1B
- Melatonin receptor
- 1B
- Melatonin receptor 1C
- Melatonin receptor 1A
- Rhodopsin-like receptors
- 5-HT1B receptor
- G protein-coupled receptor
- Vasopressin receptor 1B
- Adrenergic receptor
