• Source: Pol (HIV)

Pol (DNA polymerase) refers to a gene in retroviruses, or the protein produced by that gene.
Products of pol include:




Reverse transcriptase



Common to all retroviruses, this enzyme transcribes the viral RNA into double-stranded DNA.




Integrase



This enzyme integrates the DNA produced by reverse transcriptase into the host's genome.




Protease



A protease is any enzyme that cuts proteins into segments. HIV's gag and pol genes do not produce their proteins in their final form, but as larger combination proteins; the specific protease used by HIV cleaves these into separate functional units. Protease inhibitor drugs block this step.




See also


Gag/pol translational readthrough site




External links


Gene+Products,+pol at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
pol+Gene+Products,+Human+Immunodeficiency+Virus at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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