• Source: PROX1

Prospero homeobox protein 1 is a protein that in humans is encoded by the PROX1 gene. The Prox1 gene is critical for the development of multiple
tissues. Prox1 activity is necessary and sufficient to specify a lymphatic endothelial cell fate in endothelial progenitors located in the embryonic veins.




Interactions


PROX1 has been shown to interact with EP300.




Production


PROX1 is produced primarily in the dentate gyrus in the mouse, and in the dentate gyrus and white matter in humans. Gene expression data for mouse, human and macaque from the Allen Brain Atlases can be found here.




Clinical significance


PROX1 is used as a marker for lymphatic endothelium in biopsy samples.




Homologous gene


PROX2




References






Further reading






External links


PROX1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Overview of all the structural information available in the PDB for UniProt: Q92786 (Prospero homeobox protein 1) at the PDBe-KB.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Kata Kunci Pencarian:

• PROX1
• Lymph sacs
• Lymphangiogenesis
• Schlemm's canal
• Guillermo Oliver
• Prospero (disambiguation)
• List of human transcription factors
• Subarachnoid lymphatic-like membrane
• List of human protein-coding genes 3
• Meningeal lymphatic vessels