• Source: Pure red cell aplasia

Pure red cell aplasia (PRCA) or erythroblastopenia refers to a type of aplastic anemia affecting the precursors to red blood cells but usually not to white blood cells. In PRCA, the bone marrow ceases to produce red blood cells. There are multiple etiologies that can cause PRCA. The condition has been first described by Paul Kaznelson in 1922.




Signs and symptoms


Signs and symptoms may include:

Pale appearance
Rapid heart rate
Fatigue




Causes


Causes of PRCA include:




Diagnosis






Treatment


PRCA is considered an autoimmune disease as it will respond to immunosuppressant treatment such as cyclosporin in many patients, though this approach is not without risk.
It has also been shown to respond to treatments with rituximab and tacrolimus.
For cases related to B19 parvovirus, administration of commercial immunoglobulin can treat or cure parvovirus by replacing neutralizing antibodies.




See also


Diamond–Blackfan anemia (genetic red cell aplasia)
Aplastic anemia (aplasia affecting other bone marrow cells as well)




References






External links

Kata Kunci Pencarian:

• Pure red cell aplasia
• Aplasia
• Diamond–Blackfan anemia
• Aplastic anemia
• Red blood cell
• Hematologic disease
• Reticulocytopenia
• Erythropoiesis-stimulating agent
• Thymoma
• Apheresis