- Source: Quinaldine
Quinaldine or 2-methylquinoline is an organic compound with the formula CH3C9H6N. It is one of the methyl derivatives of the heterocyclic compound quinoline. It is bioactive and is used in the preparation of various dyes. It is a colorless oil but commercial samples can appear colored.
Production and reactions
Quinaldine is recovered from coal tar. It can be prepared from aniline and paraldehyde via Skraup synthesis or from aniline and crotonaldehyde via Doebner-von Miller variation of the Skraup reaction.
Hydrogenation of quinaldine gives 2-methyltetrahydroquinoline. This reduction can be conducted enantioselectively.
Properties
Quinaldine has critical point at 787 K and 4.9 MPa and its refractive index is 1.8116.
Uses
Quinaldine is used in manufacturing anti-malaria drugs, dyes and food colorants (e.g., Quinoline Yellows, pinacyanol). It is the precursor to the pH indicator Quinaldine Red.
Quinaldine sulfate is an anaesthetic used in fish transportation. In some Caribbean islands it is used to facilitate the collection of tropical fish from reefs.
References
External links
MSDS at Science Lab
Method of purifying quinaldine
Chisholm, Hugh, ed. (1911). "Quinoline" . Encyclopædia Britannica. Vol. 22 (11th ed.). Cambridge University Press. pp. 758–760.
Kata Kunci Pencarian:
- Quinaldine
- Quinaldine red
- N-Acetylanthranilic acid
- Quinoline Yellow SS
- Lepidine
- List of drugs: Q
- 2-Methyltetrahydroquinoline
- Aldol
- Pinacyanol
- Beckton Gas Works
