- Source: SN-38
SN-38 is an antineoplastic drug. It is the active metabolite of irinotecan (an analog of camptothecin - a topoisomerase I inhibitor) but has 1000 times more activity than irinotecan itself. In vitro cytotoxicity assays show that the potency of SN-38 relative to irinotecan varies from 2- to 2000-fold.
SN38 is formed via hydrolysis of irinotecan by carboxylesterases and metabolized via glucuronidation by UGT1A1.
The variant of UGT1A1 in ~10% of Caucasians which leads to poor metabolism of SN-38 predicts irinotecan toxicity, as it is then less easily excreted from the body in its SN-38 glucuronide form.
SN-38 and its glucuronide are lost into the bile and intestines. It can cause the symptoms of diarrhoea and myelosuppression experienced by ~25% of the patients administered irinotecan.
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles.
See also
NK012, a nanodevice formulation of SN-38
Sacituzumab govitecan, an antibody-drug conjugate that uses SN-38 as the cytotoxic drug.
References
Kata Kunci Pencarian:
- Provinsi di Indonesia
- 2009 SN
- Maṅgala Sutta
- Stronsium
- Saṅkhāra
- Kabupaten Hulu Sungai Selatan
- 23 November
- Kota Banjarmasin
- SN Brussels Airlines
- Tabel konfigurasi elektron
- SN-38
- Irinotecan
- Stalnoi Nagrudnik
- NK012
- 6B47 helmet
- 6B7 helmet
- VKPO uniform
- 6B3 ballistic vest
- 6B45 ballistic vest
- Sacituzumab govitecan
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The Count of Monte-Cristo (2024)
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