- Source: Trans-activation response element
The HIV trans-activation response (TAR) element is an RNA element which is known to be required for the trans-activation of the viral promoter and for virus replication. The TAR hairpin is a dynamic structure that acts as a binding site for the Tat protein, and this interaction stimulates the activity of the long terminal repeat promoter.
Further analysis has shown that TAR is a pre-microRNA that produces mature microRNAs from both strands of the TAR stem-loop.
These miRNAs are thought to prevent infected cells from undergoing apoptosis by downregulating the genes ERCC1, IER3, CDK9, and Bim.
Human polyomavirus 2 (JC virus) contains a TAR-homologous sequence in its late promoter that is responsive to HIV-1 derived Tat.
References
External links
Page for Trans-activation response element (TAR) at Rfam
miRBase page for hiv1-mir-TAR
Kata Kunci Pencarian:
- CREB3
- Ekspresi gen
- Reseptor vitamin D
- BCAR1
- Trans-activation response element
- Tar (disambiguation)
- Trans-regulatory element
- Structure and genome of HIV
- Tat (HIV)
- Long terminal repeat
- TAR DNA-binding protein 43
- Unfolded protein response
- Regulatory sequence
- Cis-regulatory element
