- Source: TRNA(His) guanylyltransferase
tRNA(His) guanylyltransferase (EC 2.7.7.79, histidine tRNA guanylyltransferase, Thg1p, Thg1) is an enzyme with systematic name p-tRNA(His):GTP guanylyltransferase (ATP-hydrolysing). This enzyme catalyses the following chemical reaction
p-tRNA(His) + ATP + GTP
⇌
{\displaystyle \rightleftharpoons }
pppGp-tRNA(His) + AMP + diphosphate (overall reaction)
(1a) p-tRNA(His) + ATP
⇌
{\displaystyle \rightleftharpoons }
App-tRNA(His) + diphosphate
(1b) App-tRNA(His) + GTP
⇌
{\displaystyle \rightleftharpoons }
pppGp-tRNA(His) + AMP
The enzyme requires a divalent cation for activity.
References
External links
TRNA(His)+guanylyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)