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- The Cask of Amontillado
- Real ale
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- Cask (disambiguation)
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- Cask strength
- Proper Pour Cabernet Cask 2024 | Boulevard Brewing Co.
- I made a map of breweries and bars that heavily feature cask …
- What exactly are the differences between Cask, Draught
- Cask Ale Connecticut? | Community - BeerAdvocate
- Cask Appreciation: Piston or Gravity Dispense - BeerAdvocate
- J.W. Lees Harvest Ale (Port Cask) - BeerAdvocate
- Michelob Winter's Bourbon Cask Ale | Anheuser-Busch
- Doom Bar | Sharp's Brewery - BeerAdvocate
- Java Cask | Victory Brewing Company - Downingtown
- J.W. Lees Harvest Ale (Lagavulin Whisky Cask) - BeerAdvocate
CASK GudangMovies21 Rebahinxxi LK21
Peripheral plasma membrane protein CASK is a protein that in humans is encoded by the CASK gene. This gene is also known by several other names: CMG 2 (CAMGUK protein 2), calcium/calmodulin-dependent serine protein kinase 3 and membrane-associated guanylate kinase 2. CASK gene mutations are the cause of XL-ID with or without nystagmus and MICPCH, an X-linked neurological disorder.
Gene
This gene is located on the short arm of the X chromosome (Xp11.4). It is 404,253 bases in length and lies on the Crick (minus) strand. The encoded protein has 926 amino acids with a predicted molecular weight of 105,123 daltons.
Function
This protein is a multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. It interacts with the transcription factor TBR1 and binds to several cell-surface proteins including neurexins and syndecans.
Clinical importance
This gene has been implicated in X-linked mental retardation, including specifically mental retardation and microcephaly with pontine and cerebellar hypoplasia. The role of CASK in disease is primarily associated with a loss of function (under expression) of the CASK gene as a result of a deletion, missense or splice mutation. It appears that mutations in the gene lead to diminished amounts of the protein being coded. As a result, CASK is unable to form complexes with other proteins leading to a cascade of events. Research has shown there is significant down-regulation of the genes involved in pre-synaptic development and of CASK protein interactors.
Males affected by CASK variants tend to have more severe symptoms than females due to the X-linked nature of the disease. These genetic issues are often fatal in the womb for male embryos or else lead to infant mortality. Females with CASK mutations have variable phenotypes with moderate to severe intellectual disability. CASK missense mutations and some splice mutations can lead to the milder neurodevelopmental phenotype.
CASK related disorders are mainly found in girls. The prevalence is unknown but generally thought to be below 400 cases worldwide. Patients are often born healthy but within the first few months of life show progressive microcephaly. Although there can be prenatal deceleration of head circumference growth, the majority of cases will not be diagnosed according to current recommendations for fetal CNS routine assessment.
The exact mode of pathology is not clear, but evidence from mice models indicates CASK deficiency in neurones causes the following effects:
reduced levels of associated proteins such as Mint1 and neurexin
Higher levels of Neuroligin 1
Increased glutamate release at synapses and reduced GABA release affecting the E/I balance in maturing neural circuits
Down-regulation of GluN2B resulting in disruption of synaptic E/I balance
Even slight changes in CASK expression in humans leads to dysregulation of the formation of presynapses, especially in inhibitory neurones.
Interactions
CASK has been shown to interact with:
KCNJ4
APBA1
ATP2B4
CINAP and TBR1
DLG1
DLG4
F11 receptor
ID1
KCNJ12
LIN7A
Nephrin
Parkin (ligase)
RPH3A
SDC2
= External links
=Project CASK - A non-profit based in the United States driving research breakthroughs to treat and cure CASK-related disorders.
CASK Research Foundation - A non-profit based in the UK for research, information and support into CASK related disorders including MICPCH
Angelina CASK Neurological Research Foundation - A non-profit based in Australia creating research grants for research into CASK gene related disorders.
References
Further reading
External links
Human CASK genome location and CASK gene details page in the UCSC Genome Browser.
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Proper Pour Cabernet Cask 2024 | Boulevard Brewing Co.
Aug 22, 2024 · Proper Pour Cabernet Cask 2024 is a American Imperial Stout style beer brewed by Boulevard Brewing Co. in Kansas City, MO. Score: 92 with 20 ratings and reviews. Last update: 02-05-2025.
I made a map of breweries and bars that heavily feature cask …
Feb 11, 2017 · I wanted to highlight businesses that are still operating and are cask forward in their offerings. If you go to one of the places on this map they should have cask beer always available and you can assume it will be of a good quality. The map is here. If you know of any places that serve 3-4+ cask beers let me know and I'll add it.
What exactly are the differences between Cask, Draught
Nov 27, 2012 · The cask has live yeast to produce carbonation and usually has to have finings put in to make it drop bright. Usually the cask has a short shelf life , like 2-4 days. Most of them are smaller in size, like 5 gallons vs 15.5 gallons for a standard keg.
Cask Ale Connecticut? | Community - BeerAdvocate
Nov 20, 2002 · Nod Hill Brewery in Ridgefield is developing a cask ale program focused on traditional English-style beers. Brewery has installed a beer engine and dedicated cellar-temp space to properly store and serve its casks and intends to serve predominantly session-strength beers from the hand pump.
Cask Appreciation: Piston or Gravity Dispense - BeerAdvocate
Nov 8, 2022 · Cask Widge: Positions the cask upright; Cask Sparkler: Aerates the ale/lager to create a denser head; Cask Breather: Aspirator that extends the life & prevents spoilage, which can deter the development; Caskerator: Kegerator with an upright dispense system (widge) + cask breather; Sizes: (Imp-gal/US-gal) Pin: 4.5/5.4; Firkin: 9/10.8 (Most Common)
J.W. Lees Harvest Ale (Port Cask) - BeerAdvocate
J.W. Lees Harvest Ale (Port Cask) is a English Barleywine style beer brewed by J.W. Lees & Co (Brewers) Ltd in Manchester, GB2, United Kingdom. Score: 92 with 492 ratings and reviews. Last update: 02-06-2025.
Michelob Winter's Bourbon Cask Ale | Anheuser-Busch
Michelob Winter's Bourbon Cask Ale is a Winter Warmer style beer brewed by Anheuser-Busch in Saint Louis, MO. Score: 67 with 573 ratings and reviews. Last update: 12-20-2023.
Doom Bar | Sharp's Brewery - BeerAdvocate
Doom Bar is inspired by its namesake, the treacherous sandbank at the mouth of the Camel Estuary near Sharps' home at Rock. Accomplished and precise, Doom Bar is the epitomy of consistency, balance and moreish appeal and is now the UK's no.1 selling cask beer. An enticing aroma of resinous hop, sweet malt and delicate roasted notes.
Java Cask | Victory Brewing Company - Downingtown
Aug 5, 2015 · Java Cask is a American Imperial Stout style beer brewed by Victory Brewing Company - Downingtown in Downingtown, PA. Score: 95 with 596 ratings and reviews. Last update: 02-13-2025.
J.W. Lees Harvest Ale (Lagavulin Whisky Cask) - BeerAdvocate
J.W. Lees Harvest Ale (Lagavulin Whisky Cask) is a English Barleywine style beer brewed by J.W. Lees & Co (Brewers) Ltd in Manchester, GB2, United Kingdom. Score: 89 with 588 ratings and reviews. Last update: 02-09-2025.