- Daftar gen penyandi protein pada manusia/2
- ILF2
- Housekeeping gene
- DNA-PKcs
- List of human protein-coding genes 2
- P-bodies
- ILF3
- CDC5L
ILF2 GudangMovies21 Rebahinxxi LK21
Interleukin enhancer-binding factor 2 is a protein that in humans is encoded by the ILF2 gene.
Function
Nuclear factor of activated T-cells (NFAT) is a transcription factor required for T-cell expression of the interleukin 2 gene. NFAT binds to a sequence in the interleukin 2 gene enhancer known as the antigen receptor response element 2. In addition, NFAT can bind RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the smaller of which is the product of this gene. The encoded protein binds strongly to the 90 kDa protein and stimulates its ability to enhance gene expression.
Interactions
ILF2 has been shown to interact with CDC5L and DNA-PKcs.
ILF2 and ILF3 have been identified as autoantigens in mice with induced lupus, in canine systemic rheumatic autoimmune disease, and as a rare finding in humans with autoimmune disease.
References
Further reading
External links
ILF2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
PDBe-KB provides an overview of all the structure information available in the PDB for Mouse Interleukin enhancer-binding factor 2 (ILF2)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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