• Source: 5-MAPB

5-MAPB, or 5-MBPB, also known as 1-(benzofuran-5-yl)-N-methylpropan-2-amine, is an entactogenic designer drug similar to MDMA in its structure and effects.




Pharmacology






= Pharmacodynamics

=
5-MAPB acts as a serotonin–norepinephrine–dopamine releasing agent with EC50Tooltip half-maximal effective concentration values for induction of monoamine release of 64 nM for serotonin, 24 nM for norepinephrine, and 41 nM for dopamine.
5-MAPB has been described by Matthew Baggott as the MDMA analogue so far known that has the closest effects and so-called "magic" to MDMA itself. Other analogues that lack the full quality of MDMA include MBDB, methylone, 6-APDB, 5-APDB, 6-APB, 5-APB, MDAT, and MDAI, among others.
5-MAPB has been marketed as a less- or non-neurotoxic alternative to MDMA. However, 5-MAPB has been found to be a dose-dependent serotonergic neurotoxin in rodents similarly to MDMA, and might also be a dopaminergic neurotoxin.




= Pharmacokinetics

=
Little formal knowledge exists on 5-MAPB. It does not form the α-methyldopamine metabolite that contributes to the neurotoxicity of MDMA or MDA. A study in rats indicated that the major metabolites of 5-MAPB are 5-APB and 3-carboxymethyl-4-hydroxymethamphetamine.




Legal Status






= Canada

=
5-MAPB is not listed itself in the CDSA but since it is structurally related to MDMA it may be considered illegal in Canada, although this has not been tested in court.




= China

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As of October 2015 5-MAPB is a controlled substance in China.




= Luxembourg

=
As of July 2021, 5-MAPB is not cited in the list of prohibited substances. Therefore, it is still a legal substance.




= United Kingdom

=
5-MAPB was originally banned in the UK in June 2013 under a Temporary class drug order. On March 5, 2014, the UK Home Office announced that 5-MAPB would be made a class B drug on 10 June 2014 alongside every other benzofuran entactogen and many structurally related drugs.




See Also


Borax combo




References

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