• Source: Hydroxymethylglutaryl-CoA reductase

In enzymology, a Hydroxymethylglutaryl-CoA reductase (EC 1.1.1.88) is an enzyme that catalyzes the chemical reaction

(R)-mevalonate + CoA + 2 NAD+



⇌


{\displaystyle \rightleftharpoons }

3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+
The 3 substrates of this enzyme are (R)-mevalonate, CoA, and NAD+, whereas its 3 products are 3-hydroxy-3-methylglutaryl-CoA, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-mevalonate:NAD+ oxidoreductase (CoA-acylating). Other names in common use include beta-hydroxy-beta-methylglutaryl coenzyme A reductase, beta-hydroxy-beta-methylglutaryl CoA-reductase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and hydroxymethylglutaryl coenzyme A reductase.




References






External links


Hydroxymethylglutaryl-CoA+reductase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

Kata Kunci Pencarian:

• Statin
• HMG-CoA reductase
• Hydroxymethylglutaryl-CoA reductase
• AMP-activated protein kinase
• HMG-CoA
• (hydroxymethylglutaryl-CoA reductase (NADPH))-phosphatase
• Hydroxymethylglutaryl-CoA reductase (NADPH)
• Dephospho-(reductase kinase) kinase
• HMG-CoA reductase family
• Familial hypercholesterolemia