• Source: Integrin alpha V

Integrin alpha-V is a protein that in humans is encoded by the ITGAV gene.




Function


ITGAV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; ITGB1, ITGB3, ITGB5, ITGB6, and ITGB8), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction.




Alpha V class integrins


In mammals the integrins that include alpha-V are :




Clinical significance


Overexpression of the ITGAV gene is associated with progression and spread of colorectal cancer, and prostate cancer.




As a drug target


The mAbs intetumumab, and abituzumab target this protein which is found on some tumour cells.




See also


Cluster of differentiation




References






Further reading






External links


CD51+Antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
ITGAV Info with links in the Cell Migration Gateway Archived 2014-12-11 at the Wayback Machine

Kata Kunci Pencarian:

• Kanker
• Integrin alpha V
• Integrin alpha M
• Alpha 5
• Alpha-v beta-3
• Integrin
• Integrin beta 6
• Integrin alpha X
• Integrin alpha L
• Integrin alpha 5
• TGF beta Activation