- Source: Interleukin-21 receptor
Interleukin 21 receptor is a type I cytokine receptor. IL21R is its human gene.
The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma chain (γc), a receptor subunit also shared by the receptors for interleukin 2 (IL2), interleukin 7 (IL7) and interleukin 15 (IL15). This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants encoding the same protein have been described.
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Further reading
Kata Kunci Pencarian:
- Reseptor IL-21
- Sel B memori
- Antipiretik
- Perangkap ekstraseluler neutrofil
- Kortisol
- Sistem imun
- Covid-19
- Kanker
- Strok
- Tiazolidindion
- Interleukin-21 receptor
- Common gamma chain
- Interleukin-6 receptor
- Interleukin-7 receptor
- Interleukin 10
- Interleukin-1 receptor
- Interleukin-3 receptor
- Interleukin-12 receptor
- Interleukin-22 receptor
- Interleukin-1 receptor antagonist
