• Source: S-Adenosyl-L-homocysteine

S-Adenosyl-L-homocysteine (SAH) is the biosynthetic precursor to homocysteine. SAH is formed by the demethylation of S-adenosyl-L-methionine. Adenosylhomocysteinase converts SAH into homocysteine and adenosine.




Biological role


DNA methyltransferases are inhibited by SAH. Two S-adenosyl-L-homocysteine cofactor products can bind the active site of DNA methyltransferase 3B and prevent the DNA duplex from binding to the active site, which inhibits DNA methylation.




References






External links


BioCYC E.Coli K-12 Compound: S-adenosyl-L-homocysteine

Kata Kunci Pencarian:

• Kreatina
• S-Adenosyl-L-homocysteine
• Homocysteine
• Adenosylhomocysteinase
• S-Adenosyl methionine
• Nicotinamide N-methyltransferase
• S-ribosylhomocysteine lyase
• Arsenite methyltransferase
• Amine N-methyltransferase
• (S)-coclaurine-N-methyltransferase
• L-olivosyl-oleandolide 3-O-methyltransferase