- Source: Sonidegib
Sonidegib (INN), sold under the brand name Odomzo, is a medication used to treat cancer.
Sonidegib is a Hedgehog signaling pathway inhibitor (via smoothened antagonism).
Approvals and indications
It was approved for medical use in the United States and in the European Union in 2015
It is indicated for the treatment of adults with locally advanced basal-cell carcinoma that has recurred following surgery or radiation therapy, or those who are not candidates for surgery or radiation therapy.
Pharmacology
Sonidegib is administered by mouth. Common side effects include muscle spasms, hair loss, fatigue, abdominal pain, nausea, headache, and weight loss.
Sonidegib binds to and inhibits smoothened to inhibit activation of the Hedgehog pathway. Sonidegib is primarily metabolized by CYP3A and is eliminated hepatically.
Development
It has been investigated as a potential treatment for:
Pancreatic cancer
Breast cancer
Basal cell carcinoma of the skin
Small cell lung cancer
Medulloblastoma
Advanced solid tumors (including ovarian, breast, pancreatic, stomach, oesophageal cancers and glioblastoma multiforme)
Acute leukemia and chronic myeloid leukemia
Myelofibrosis and essential thrombocythaemia
It has demonstrated significant efficacy against melanoma in vitro and in vivo. It also demonstrated efficacy in a mouse model of pancreatic cancer.
References
External links
"Sonidegib". Drug Information Portal. U.S. National Library of Medicine.
"Sonidegib phosphate". Drug Information Portal. U.S. National Library of Medicine.
Kata Kunci Pencarian:
- Itrakonazol
- Tatanama Obat
- Sonidegib
- Itraconazole
- Hedgehog pathway inhibitor
- Basal-cell carcinoma
- Hedgehog signaling pathway
- Novartis
- Targeted therapy
- Drug nomenclature
- ATC code L01
- Elranatamab
